原標題：世界衛(wèi)生組織/國際免疫學聯(lián)合會過敏原命名法：提供一種通用的術語
　　過敏原的系統(tǒng)命名起源于20世紀80年代早期，當時只有很少蛋白質過敏原被描述。David G. Marsh博士領導的科學家團隊基于Linnaean分類法發(fā)明了一種命名法，并在1986年進一步建立了世界衛(wèi)生組織/國際免疫學會聯(lián)盟(WHO/IUIS)過敏原命名小組委員會。它的目的是標準化抗原(過敏原)的名稱，這些抗原(過敏原)在人類中引起IgE介導的過敏。小組委員會于一九八六年首次發(fā)表修訂后的過敏原名單，直至一九九四年，該名單的數(shù)量不斷增加。從1994年到2007年，該數(shù)據(jù)庫是一個在線文本表格，隨后轉變?yōu)橐粋€更容易更新的網站。過敏原列表成為過敏原命名數(shù)據(jù)庫(www.allergen.org)，目前包含了大約880種不同來源的蛋白質。小組委員會包括臨床和分子變態(tài)反應學專家。他們使用小組委員會制定的以證據(jù)為基礎的標準來審查提交的過敏原候選蛋白。審查過程評估提交的過敏原生化分析報告和證據(jù)，目的是在發(fā)布前確定過敏原名稱。該小組委員會負責維護和修訂數(shù)據(jù)庫，并應對不斷出現(xiàn)的挑戰(zhàn)，因為新的“組學”技術提供了越來越多關于潛在新過敏原的數(shù)據(jù)。大多數(shù)期刊發(fā)表新過敏原信息都需要一個正式的過敏原名稱，包括向世衛(wèi)組織/IUIS過敏原命名小組委員會提交機密數(shù)據(jù)，來證明過敏樣本血清與純化蛋白的結合。


延伸閱讀
Molecular Immunology
WHO/IUIS Allergen Nomenclature: Providing a common language
https://doi.org/10.1016/j.molimm.2018.03.003
Abstract:
A systematic nomenclature for allergens originated in the early 1980s, when few protein allergens had been described. A group of scientists led by Dr. David G. Marsh developed a nomenclature based on the Linnaean taxonomy, and further established the World Health Organization/International Union of Immunological Societies (WHO/IUIS) Allergen Nomenclature Sub-Committee in 1986. Its stated aim was to standardize the names given to the antigens (allergens) that caused IgE-mediated allergies in humans. The Sub-Committee first published a revised list of allergen names in 1986, which continued to grow with rare publications until 1994. Between 1994 and 2007 the database was a text table online, then converted to a more readily updated website. The allergen list became the Allergen Nomenclature database (www.allergen.org), which currently includes approximately 880 proteins from a wide variety of sources. The Sub-Committee includes experts on clinical and molecular allergology. They review submissions of allergen candidates, using evidence-based criteria developed by the Sub-Committee. The review process assesses the biochemical analysis and the proof of allergenicity submitted, and aims to assign allergen names prior to publication. The Sub-Committee maintains and revises the database, and addresses continuous challenges as new “omics” technologies provide increasing data about potential new allergens. Most journals publishing information on new allergens require an official allergen name, which involves submission of confidential data to the WHO/IUIS Allergen Nomenclature Sub-Committee, sufficient to demonstrate binding of IgE from allergic subjects to the purified protein.
First Author:
Correspondence:
All Authors:
AnnaPomésaJanetM.DaviesbChristianeHilgerdThomasHolzhausereJonasLidholmfAndreas L.LopatagGeoffreyA.MuellerhAndreasNandyiChristianRadauerjSannyK.ChankUtaJappelJ?rgKleine-TebbemWayneR.ThomasnMartinD.ChapmanaMariannevanHageoRonaldvanReepStefanViethsq…Richard E.Goodmans
　　創(chuàng)建過敏性疾病的科研、科普知識交流平臺，為過敏患者提供專業(yè)診斷、治療、預防的共享平臺。