原標(biāo)題：
　　內(nèi)陸城市出生隊(duì)列中有哮喘和鼻炎兒童與無哮喘和鼻炎中蟑螂過敏原組份分析
　　①背景：蟑螂是室內(nèi)過敏原的重要來源之一，可導(dǎo)致IgE敏化，并可發(fā)展為鼻炎和哮喘。②目的：進(jìn)行蟑螂過敏原組份分析，確定與哮喘和鼻炎相關(guān)的過敏原、抗體水平和致敏模式。③方法：在兩組蟑螂敏感的有哮喘和鼻炎（n = 19）、無哮喘和鼻炎（n = 28）的10歲兒童中檢測(cè)總蟑螂過敏原及8種蟑螂過敏原組份特異性IgE、IgG、IgG4抗體。過敏原組份特異性抗體水平在吸附有蟑螂第1、2、4、5、6、7、9和11組重組過敏原的鏈霉親和素ImmunoCAP上進(jìn)行，而蟑螂特異性IgE用i6 ImmunoCap檢測(cè)。④結(jié)果：有哮喘和鼻炎患兒和無哮喘和鼻炎患兒之間不同的是蟑螂過敏原組份和提取物特異性IgE水平，而不是IgG或IgG4。特別是，識(shí)別更多的蟑螂過敏原組份、更高的過敏原特異性IgE與疾病的發(fā)生相關(guān)。兩組中均發(fā)現(xiàn)存在致敏模式的差異及無免疫顯性過敏原的存在。過敏原組份特異性IgE的總和與總蟑螂過敏原（提取物）特異性IgE之間有良好的相關(guān)性(r = 0.86; p <0.001)。⑤結(jié)論：8種蟑螂過敏原組份分析顯示，與哮喘和鼻炎的表現(xiàn)相關(guān)的IgE反應(yīng)性具有顯著的差異。過敏原特異性IgE的水平以及致敏譜與哮喘和鼻炎有關(guān)。
延伸閱讀
JACI  
Cockroach allergen component analysis of children with or without asthma and rhinitis in an inner-city birth cohort
DOI: https://doi.org/10.1016/j.jaci.2019.05.036
Abstract
Background
Cockroach is one of the most important sources of indoor allergens that can lead to IgE sensitization and to the development of rhinitis and asthma.
Objective
To perform a cockroach allergen component analysis to determine the allergens and antibody levels and patterns of sensitization that are associated with asthma and rhinitis.
Methods
Antibody levels (IgE, IgG and IgG4) to total cockroach and to eight cockroach allergens were determined in two groups of cockroach sensitized 10-year old children with (n = 19) or without (n = 28) asthma and rhinitis. Allergen-specific antibody levels were measured in streptavidin ImmunoCAPs loaded with each of the recombinant allergens from groups 1, 2, 4, 5, 6, 7, 9, and 11, and total cockroach-specific IgE was measured using the i6 ImmunoCap.
Results
IgE antibody levels to cockroach allergens and extract, but not IgG or IgG4, differed between subjects with and without asthma and rhinitis. Specifically, recognition of more cockroach allergens, with higher allergen-specific IgE, were associated with disease. Variable patterns of sensitization, with no immunodominant allergens, were found in both groups. There was a good correlation between the sum of allergen-specific IgE and total cockroach IgE (r = 0.86; p <0.001).
Conclusions
Component analysis of eight cockroach allergens revealed significant differences in IgE reactivity associated with the presence of asthma and rhinitis. Allergen-specific IgE titers and sensitization profiles were associated with asthma and rhinitis.
All Author:
Anna Pomés Jill Glesner Agustin Calatroni Cindy M. Visness Robert A. Wood George T. O’Connor Meyer Kattan Leonard B. Bacharier Lisa M. Wheatley James E. Gern William W. Busse
· Genome Institute of Singapore, Agency for Science, Technology and Research Singapore, Singapore
　　創(chuàng)建過敏性疾病的科研、科普知識(shí)交流平臺(tái)，為過敏患者提供專業(yè)診斷、治療、預(yù)防的共享平臺(tái)。