原標(biāo)題：表觀遺傳與過(guò)敏：從基礎(chǔ)機(jī)理到臨床應(yīng)用
　　在西方，過(guò)敏性疾病在上升，眾所周知的過(guò)敏保護(hù)與驅(qū)動(dòng)因素如微生物和飲食暴露、污染和吸煙通過(guò)改變表觀遺傳景觀來(lái)介導(dǎo)它們的影響力。這里，我們回顧了過(guò)敏性疾病中參與的表觀遺傳學(xué)改變，總結(jié)和批判性地評(píng)估表觀遺傳學(xué)相關(guān)研究中經(jīng)驗(yàn)教訓(xùn)。我們展示了表觀遺傳學(xué)在臨床中的各種應(yīng)用：作為診斷工具，評(píng)估免疫治療后的耐受或在早期可能性地預(yù)測(cè)治療的效果。另外，新的技術(shù)進(jìn)步如表觀基因組編輯一種脫氧核酶在將來(lái)可以對(duì)表觀基因組進(jìn)行目標(biāo)性的修飾并提供新的治療工具。


　　延伸閱讀
Epigenomics  
Epigenetics  and allergy: from basic mechanisms to clinical applications
DOI
Abstract:
Allergic diseases are on the rise in the Western world and well-known allergy protecting and -driving factors such as microbial and dietary exposure, pollution and smoking mediate their influence through alterations of the epigenetic landscape.Here, we review key facts on the involvement of epigenetic modifications in allergic diseases and summarize and critically evaluate the lessons learned from epigenome-wide association studies. We show the potential of epigenetic changes for various clinical applications: as diagnostic tools, to assess tolerance following immunotherapy or possibly predict the success of therapy at an early time point. Furthermore, new technological advances such as epigenome editing an DNAzymes will allow targeted alterations of the epigenome in the future and provide novel therapeutic tools.
First Author:
DP Potaczek ， H Harb ， S Michel ， BA Alhamwe ， H Renz ， ...
　　創(chuàng)建過(guò)敏性疾病的科研、科普知識(shí)交流平臺(tái)，為過(guò)敏患者提供專業(yè)診斷、治療、預(yù)防的共享平臺(tái)。