原標(biāo)題：特應(yīng)性皮炎病人的微生物組學(xué)
　　作為與環(huán)境接觸面，皮膚是人體一個復(fù)雜的生態(tài)系統(tǒng)，由許多微生物在一個既定的平衡中共存。皮膚微生物組抑制病原菌(如金黃色葡萄球菌)的定植，是表皮屏障功能的重要組成部分。此外，由于微生物可以調(diào)節(jié)先天免疫反應(yīng)和適應(yīng)性免疫反應(yīng)，共體和免疫系統(tǒng)之間的相互作用也得到了承認(rèn)。寄主與寄主之間的相互作用也會影響嬰兒免疫系統(tǒng)的發(fā)育，進(jìn)而影響哮喘和特應(yīng)性皮炎(AD)等疾病的發(fā)生。在以后的生活中，皮膚微生物群參與了皮膚病的發(fā)展和過程。因此，在AD患者中，微生物組多樣性的降低與疾病的嚴(yán)重程度和致病菌(如金黃色葡萄球菌)的定植增加有關(guān)。早期臨床研究表明，局部應(yīng)用共生菌(如人葡萄球菌或玫瑰單胞菌黏膜)可降低AD的嚴(yán)重程度，這支持了共生菌在降低AD患者金黃色葡萄球菌定植中的重要作用。進(jìn)一步了解皮膚微生物群及其在調(diào)節(jié)AD等皮膚疾病過程中的作用，可能會產(chǎn)生新的治療策略。


延伸閱讀
JACI    Volume 143, Issue 1, January 2019, Pages 26-35
[IF:13.1]
The microbiome in patients with atopic dermatitis
https://doi.org/10.1016/j.jaci.2018.11.015
As an interface with the environment, the skin is a complex ecosystem colonized by many microorganisms that coexist in an established balance. The cutaneous microbiome inhibits colonization with pathogens, such as Staphylococcus aureus, and is a crucial component for function of the epidermal barrier. Moreover, crosstalk between commensals and the immune system is now recognized because microorganisms can modulate both innate and adaptive immune responses. Host-commensal interactions also have an effect on the developing immune system in infants and, subsequently, the occurrence of diseases, such as asthma and atopic dermatitis (AD). Later in life, the cutaneous microbiome contributes to the development and course of skin disease. Accordingly, in patients with AD, a decrease in microbiome diversity correlates with disease severity and increased colonization with pathogenic bacteria, such as S aureus. Early clinical studies suggest that topical application of commensal organisms (eg, Staphylococcus hominis or Roseomonas mucosa) reduces AD severity, which supports an important role for commensals in decreasing S aureus colonization in patients with AD. Advancing knowledge of the cutaneous microbiome and its function in modulating the course of skin disorders, such as AD, might result in novel therapeutic strategies.
All Author:
Amy S.PallerMSc, MDaHeidi H.KongMD, MHScbPatrickSeedMD, PhDaShrutiNaikPhDcTiffany C.ScharschmidtMDdRichard L.GalloMD, PhDeThomasLugerMDfAlan D.IrvineMD, DScg
　　創(chuàng)建過敏性疾病的科研、科普知識交流平臺，為過敏患者提供專業(yè)診斷、治療、預(yù)防的共享平臺。