原標題：全球兒童和成人慢性蕁麻疹的患病率：薈萃分析系統(tǒng)評價
背景：蕁麻疹是一種常見的皮膚病，但從人群研究尤其是慢性蕁麻疹的研究中獲得可靠的評估是很少見的。本研究的目的是通過對世界范圍內基于人群研究進行系統(tǒng)地評估，總結慢性蕁麻疹的患病率。
方法：我們在PUBMED和EMBASE中進行了系統(tǒng)搜索，包括基于人群的橫斷面或隊列設計研究，以及基于健康保險/系統(tǒng)數(shù)據(jù)庫的研究，使用特定的研究工具評估偏倚的風險。對于薈萃分析，我們使用了隨機效應模型。  
結果：本研究包括18項系統(tǒng)評價和11項薈萃分析，包括來自超過8600萬參與者的數(shù)據(jù)。偏倚風險是中等的，但研究之間的統(tǒng)計異質性（I2）高。亞洲研究綜合顯示，慢性蕁麻疹的患病率較高（1.4%，95%-CI 0.5-2.9），高于歐洲（0.5%，0.2-1.0）和北美（0.1%，0.1-0.1）。女性患病的程度略高于男性，而在15歲以下的兒童中，患病率沒有性別差異。檢驗時間趨勢的四項研究表明，隨著時間的推移，慢性蕁麻疹的患病率呈上升趨勢。
結論：在全球范圍內，慢性蕁麻疹的患病率顯示出很大的地區(qū)差異。有必要獲取更多基于性別的，基于人口的標準化國際數(shù)據(jù)，尤其是針對兒童和青少年，不同的慢性蕁麻疹亞型以及潛在的風險和保護因素。


延伸閱讀
Allergy                                           
Prevalence of chronic urticaria in children and adults across the globe: Systematic review with meta‐analysis 
DOI: 10.1111/all.14037
Abstract:
Background: Urticaria is a frequent skin condition, but reliable prevalence estimates from population studies particularly of the chronic form are scarce.The objective of this study was to systematically evaluate and summarize the prevalence of chronic urticaria by evaluating population‐based studies worldwide. Methods: We performed a systematic search in PUBMED and EMBASE for population‐based studies of cross‐sectional or cohort design and studies based on health insurance/system databases. Risk of bias was assessed using a specific tool for prevalence studies. For meta‐analysis, we used a random effects model.
Results: Eighteen studies were included in the systematic evaluation and 11 in the meta‐analysis including data from over 86 000 000 participants. Risk of bias was mainly moderate, whereas the statistical heterogeneity (I2) between the studies was high. Asian studies combined showed a higher point prevalence of chronic urticaria (1.4%, 95%‐CI 0.5‐2.9) than those from Europe (0.5%, 0.2‐1.0) and Northern American (0.1%, 0.1‐0.1). Women were slightly more affected than men, whereas in children < 15 years we did not find a sex‐specific difference in the prevalence. The four studies that examined time trends indicated an increasing prevalence of chronic urticaria over time.
Conclusion: On a global level, the prevalence of chronic urticaria showed considerable regional differences. There is a need to obtain more sex‐specific population based and standardized international data particularly for children and adolescents,different chronic urticaria subtypes and potential risk and protective factors.
First Author:
Julia Fricke
Correspondence:
Julia Fricke, Institute for Social Medicine,Epidemiology and Health Economics,Charité‐Universit?tsmedizin Berlin,Luisenstr. 57, 10117 Berlin, Germany.
All Authors:
Julia Fricke, Gabriela ávila, Theresa Keller, Karsten Weller, Susanne Lau, Marcus Maurer, Torsten Zuberbier, homas Keil
　　創(chuàng)建過敏性疾病的科研、科普知識交流平臺，為過敏患者提供專業(yè)診斷、治療、預防的共享平臺。