原標(biāo)題：大豆過敏的分子組份檢測分析
　?、俅蠖惯^敏是最常見的食物過敏之一。大豆組分貯藏蛋白Gly m4、m5、m6特異性IgE檢測，被認(rèn)為是提高大豆過敏反應(yīng)（系統(tǒng)性和局部）特異性鑒定能力的一種方法②本研究回顧性分析了國家實(shí)驗(yàn)室對樣本進(jìn)行Gly m4、5、6特異性 IgE (Phadia ImmunoCAP)檢測的結(jié)果。根據(jù)目前的研究，利用國際標(biāo)準(zhǔn)0.35kU/L作為IgE檢測陽性的臨界值，將未鑒定的患者樣本的數(shù)據(jù)編入危險組。③在樣本組中，46%的患者對至少一種大豆組份有反應(yīng)。在這些患者中，39%的患者僅對Gly m5和Gly 6有反應(yīng)，這兩種成分最能說明大豆對患者有嚴(yán)重的全身反應(yīng)。對Gly m4有反應(yīng)的患者僅占37%，對所有成分均有反應(yīng)的患者占15%。少數(shù)患者單獨(dú)對Gly m5或6有反應(yīng)或與Gly m4相關(guān)。近60% (<10歲)陽性患兒對Gly m5和6均有應(yīng)答，僅14%對Gly m4有應(yīng)答。大于10歲的患者對Gly m4的反應(yīng)明顯高于m5和m6(54% - 24%)。
　?、芊肿咏M份過敏檢測在評估大豆過敏風(fēng)險和建立適當(dāng)?shù)尼t(yī)療應(yīng)答方面邁出了重要的一步。在識別系統(tǒng)反應(yīng)和局部/非特異性反應(yīng)上，它們的標(biāo)記物之間存在顯著特異性，表明該信息對患者及其家屬有重要意義。
延伸閱讀
JACI:
Analysis of Soy Allergy Using Molecular Component Testing
DOI: https://doi.org/10.1016/j.jaci.2017.12.843 Abstract:
Background
Rationale
Soy allergy is one of the most common food allergies. The presence of IgE specific to soy component storage proteins Gly m4, m5, and m6 has been indicated as a means to improve the specific identification of systemic and local soy allergic reactions.
Methods
A retrospective review of national laboratory data was performed over samples testing for IgE to Gly m4, 5, and 6 (Phadia ImmunoCAP). Data from de-identified patient samples were compiled into risk groups based on current research utilizing the international standard cutoff of 0.35kU/L as a positive test for IgE.
Results
Of the sample set, 46% of patients were responsive to at least one soy component. Of these, 39% of patients display response to only Gly m5 and 6, the components most indicative of a severe and systemic response to soy. Patients responsive to Gly m4 only represented 37%, and 15% were responsive to all components. Few patients were responsive to Gly m5 or 6 separately or associated with Gly m4. Nearly 60% of positive pediatric (<10Y) patients were responsive to both Gly m5 and 6 and only 14% to Gly m4 alone. Patients older than 10 years predominantly respond to Gly m4 alone over m5 and m6 only (54% to 24%).
Conclusions
Molecular component allergy testing represents a major step forward in assessing risk of soy allergies and constructing an appropriate medical response. A significant rate of specificity between the identification of markers for systemic and local/non-specific reactions indicates the importance of this information for patients and their families.
All Author:
Dallas C. Jones, Amanda L. Hays Michelle L. Altrich PhD
　　創(chuàng)建過敏性疾病的科研、科普知識交流平臺，為過敏患者提供專業(yè)診斷、治療、預(yù)防的共享平臺。