原標題：歐洲榛子過敏的體外組份診斷
　?、賹﹂蛔拥氖澄镞^敏同時伴或不伴花粉過敏。②我們試圖在西班牙、瑞士和丹麥三個國家中評估一組榛子過敏原，用于榛子過敏的診斷。③52例對榛子雙盲、安慰劑對照食物挑戰(zhàn)試驗結果呈陽性的患者;5例有過敏反應史;花粉過敏但榛子耐受62例;63例非特應性受試者作為對照。采用ImmunoCAP法對榛子提取物、重組榛子過敏原(rCor a 1.04、rCor a 2、rCor a 8、rCor a 11)、天然過敏原(nCor a 9、nCor a Bd8K、nCor a Bd11K)的血清特異性IgE水平進行分析。④榛子過敏患者中,91%(瑞士/西班牙，100%;丹麥，75%)有對榛子提取物，75%對rCor a1.04, 42%對rCor a2, 28%對rCor a8, 2%對rCor a11的特異性IgE。對Cor a 1.04的致敏率最高的是北部地區(qū)(瑞士/丹麥，100%;西班牙，18%)，而對脂質轉移蛋白rCor a8的IgE在西班牙占優(yōu)勢(西班牙，71%;瑞士,15%;丹麥,5%)。對抑制蛋白 rCor a2的IgE分布均勻(40% ~ 45%)。在花粉過敏的對照組中，61%的人有對榛子提取物, 69%的人對rCor a 1.04, 34%的人對rCor a 2, 10%的人對rCor a 8, 6%的人對rCor a 11的特異性IgE。
　　⑤組份診斷分析顯示，歐洲榛子過敏和榛子耐受患者的IgE譜存在顯著差異。


延伸閱讀
JACI:
Component-resolved in vitro diagnosis of hazelnut allergy in Europe
DOI: https://doi.org/10.1016/j.jaci.2009.02.005
Abstract:
Background
Background
Food allergy to hazelnut occurs both with and without concomitant pollen allergy.
Objective
We sought to evaluate a panel of hazelnut allergens for diagnosis of hazelnut allergy in Spain, Switzerland, and Denmark.
Methods
Fifty-two patients with a positive double-blind, placebo-controlled food challenge result with hazelnuts; 5 patients with a history of anaphylaxis; 62 patients with pollen allergy but hazelnut tolerance; and 63 nonatopic control subjects were included. Serum IgE levels to hazelnut extract, recombinant hazelnut allergens (rCor a 1.04, rCor a 2, rCor a 8, rCor a 11), and native allergens (nCor a 9, nCor a Bd8K, nCor a Bd11K) were analyzed by means of ImmunoCAP.
Results
Among patients with hazelnut allergy, 91% (Switzerland/Spain, 100%; Denmark, 75%) had IgE to hazelnut extract, 75% to rCor a 1.04, 42% to rCor a 2, 28% to rCor a 8, and 2% to rCor a 11. The highest rate of sensitization to Cor a 1.04 was found in the northern regions (Switzerland/Denmark, 100%; Spain, 18%), whereas IgE to the lipid transfer protein rCor a 8 prevailed in Spain (Spain, 71%; Switzerland, 15%; Denmark, 5%). IgE to profilin rCor a 2 was equally distributed (40% to 45%). Among control subjects with pollen allergy, 61% had IgE to hazelnut extract, 69% to rCor a 1.04, 34% to rCor a 2, 10% to rCor a 8, and 6% to rCor a 11.
Conclusion
Component-resolved in vitro analyses revealed substantial differences in IgE profiles of hazelnut allergic and hazelnut tolerant patients across Europe.
All Author:
Kirsten Skamstrup Hansen, MD, PhD'Correspondence information about the author MD, PhD Kirsten Skamstrup Hansen Email the author MD, PhD Kirsten Skamstrup Hansen, Barbara K. Ballmer-Weber, MD, PhD, Joaquin Sastre, MD, PhD, Jonas Lidholm PhD, Kerstin Andersson, PhD, Hubert Oberhofer, MD, Magdalena Lluch-Bernal, MD, Jonas ?stling, PhD, Lars Mattsson, PhD,Frauke Schocker, hD, Stefan Viet, PhD, Lars K. Poulsen, PhDPlumX Metric
　　創(chuàng)建過敏性疾病的科研、科普知識交流平臺，為過敏患者提供專業(yè)診斷、治療、預防的共享平臺。