原標題：分子學過敏原特異性IgE檢測是基于過敏原提取物的致敏性分析的補充
　　基于過敏原分子組份分析的診斷性的IgE抗體檢測已經(jīng)以單一和多重陣列檢測的形式出現(xiàn)。他們同時使用天然和重組的過敏原分子(有時相互結(jié)合)來補充基于提取物的過敏原IgE抗體分析?？色@得的致敏分子總數(shù)已達到有助于診斷的水平;然而，需要更多的分子來涵蓋所有臨床上重要過敏原的特異性。因此，在可預見的未來，分子過敏原特異性IgE分析仍將是過敏原提取物IgE抗體分析在過敏診斷中的補充。因此，它將促使制造商能夠提高用于體外檢測的提取物的質(zhì)量。與組份診斷檢測相關(guān)的兩個最喜人的診斷進展是，有可能通過包含當前提取物和體外分析中未充分表達的過敏原來提高診斷靈敏度，并通過考慮過敏原交叉反應性信息來提高診斷特異性。特別是后者的應用仍在開發(fā)中。這就需要進一步研究血清學交叉反應的臨床相關(guān)性。2015美國過敏、哮喘與免疫學學會(J Allergy Clin Immunol Pract 2015;3:863-9)


延伸閱讀
JACI：
Molecular Allergen-Specific IgE Assays as a Complement to Allergen Extract-Based Sensitization Assessment
http://dx.doi.org/10.1016/j.jaip.2015.09.013
Molecular allergen- based component-resolved diagnostic IgE antibody tests have emerged in the form of singleplex assays and multiplex arrays. They use both native and recombinant allergen molecules, sometimes in combination with each other, to supplement allergen extract-based IgE antibody analyses. The total number of available allergenic molecules has reached a diagnostically useful level; however, more molecules are needed to cover all the clinically important allergen specificities. Thus, for the foreseeable future, molecular allergen-specific IgE analyses will remain a supplement for initial allergen extract-based IgE antibody analyses in the diagnostic workup of the allergic patient. As a spin-off, it will enable manufacturers to improve the quality of extracts for in vitro testing. The 2 most exciting diagnostic developments linked to component-resolved diagnostic tests are the possibility to increase diagnostic sensitivity by the inclusion of allergens that are underrepresented in the current extracts and in vitro assays and to increase the diagnostic specificity by taking the information on allergen cross-reactivity into account. Particularly the latter application is still under development. This requires additional studies on the clinical relevance of serological cross-reactivity.  2015 American Academy of Allergy, Asthma & Immunology ( J Allergy Clin Immunol Pract 2015;3:863-9)
All Authors:
Rob C.AalbersePhDabJoost A.AalberseMD
　　創(chuàng)建過敏性疾病的科研、科普知識交流平臺，為過敏患者提供專業(yè)診斷、治療、預防的共享平臺。