原標(biāo)題：時間性過敏：生物鐘是如何影響過敏的
　　變態(tài)反應(yīng)性疾病的特征是臨床癥狀和實驗室參數(shù)晝夜變化明顯。最近的報告表明，生物鐘在行為和生理上以大約24小時的周期驅(qū)動著生物節(jié)律，它決定過敏反應(yīng)一天內(nèi)依賴變化的時間。新的研究還表明，生物鐘活動的中斷不僅會影響時間節(jié)奏的變化，還會增加過敏反應(yīng)的嚴(yán)重程度，甚至?xí)黾訉^敏性疾病的易感性。這些發(fā)現(xiàn)表明，生物鐘是過敏反應(yīng)的一個強有力的調(diào)節(jié)器，在過敏中起著比簡單的生物鐘更重要的作用。對這些過程的更好理解將為以前未知的過敏生物學(xué)方面提供新的見解，并可能導(dǎo)致應(yīng)用時鐘調(diào)節(jié)器治療過敏性疾病。最后，這一研究領(lǐng)域提供了一個全新的機會，讓我們考慮發(fā)達國家的現(xiàn)代生活方式如何改變過敏的臨床表現(xiàn)，因為我們的社會正迅速轉(zhuǎn)變?yōu)橐粋€晝夜節(jié)律紊亂的社會，在這個社會中，睡眠、工作和飲食習(xí)慣與內(nèi)源性晝夜節(jié)律不同步。這些發(fā)現(xiàn)可能使我們揭示更好地控制過敏性疾病的生活方式的干預(yù)。


　　延伸閱讀


JACI
Clockwork allergy: How the circadian clock underpins allergic reactions
DOI: 10.1016/j.jaci.2018.08.007
Abstract:
Allergic disease is characterized by marked day-night changes in the clinical symptoms and laboratory parameters of allergy. Recent reports suggest that the circadian clock, which drives a biological rhythm with a periodicity of approximately 24 hours in behavior and physiology, underpins a time of day–dependent variation in allergic reactions. New studies also suggest that disruption of clock activity not only influences temporal variation but can also enhance the severity of allergic reactions and even increase susceptibility to allergic disease. These findings suggest that the circadian clock is a potent regulator of allergic reactions that plays more than a simple circadian timekeeping role in allergy. A better understanding of these processes will provide new insight into previously unknown aspects of the biology of allergies and can lead to the application of clock modifiers to treat allergic disease. Finally, this area of research provides a novel opportunity to consider how modern lifestyles in the developed world are changing the clinical manifestations of allergy as our society quickly transforms into a circadian rhythm–disrupted society in which sleeping, working, and eating habits are out of sync with endogenous circadian rhythmicity. Such findings might reveal lifestyle interventions that enable us to better control allergic disease.
Author:
AtsuhitoNakaoMD, PhD
　　創(chuàng)建過敏性疾病的科研、科普知識交流平臺，為過敏患者提供專業(yè)診斷、治療、預(yù)防的共享平臺。