原標(biāo)題：2017過敏性疾病機(jī)理研究新進(jìn)展
　　本文綜述了過敏性疾病的發(fā)病機(jī)制，特別是2型先天淋巴樣細(xì)胞、TH2淋巴細(xì)胞、B細(xì)胞、樹突狀細(xì)胞、人體微生物組和屏障功能、嗜酸性粒細(xì)胞和肥大細(xì)胞方面的機(jī)理。在過去的一年里，在適應(yīng)性(TH2)和2型先天淋巴樣效應(yīng)細(xì)胞控制的2型炎癥的特征方面取得了相當(dāng)大的進(jìn)展。淋巴細(xì)胞活化、轉(zhuǎn)運(yùn)、募集和效應(yīng)細(xì)胞機(jī)制的新途徑已經(jīng)被發(fā)現(xiàn)。淋巴細(xì)胞效應(yīng)細(xì)胞應(yīng)答的可塑性是另一個(gè)取得重大進(jìn)展的領(lǐng)域。越來越多的證據(jù)將影響我們對(duì)過敏性疾病的理解以及我們預(yù)防和治療過敏的努力。
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JACI
Advances in mechanisms of allergic disease in 2017
DOI: 10.1016/j.jaci.2018.09.027
Abstract:
This review highlights advances in mechanisms of allergic disease, particularly type 2 innate lymphoid cells, TH2 lymphocytes, B cells, dendritic cells, microbiome and barrier function, eosinophils, and mast cells. During the last year, considerable progress has been made in the further characterization of type 2 inflammation controlled by both adaptive (TH2) and type 2 innate lymphoid effector cells. New pathways of lymphocyte activation, trafficking, and recruitment and effector cell mechanisms have been discovered. The plasticity of lymphocyte effector cell responses is another area in which major progress has been achieved. Accumulating evidence will influence both our understanding of allergic disease and our efforts for allergy prevention and treatment.
All Authors:
ChrysanthiSkevakiMD, PhDabHaraldRenzMDa
　　創(chuàng)建過敏性疾病的科研、科普知識(shí)交流平臺(tái)，為過敏患者提供專業(yè)診斷、治療、預(yù)防的共享平臺(tái)。