原標(biāo)題：免疫治療期間對(duì)戶塵螨的IgE、IgG4應(yīng)答的改變 
　　①研究特異性免疫治療(SIT)期間對(duì)塵螨(HDM)及其組分Der p1和Der p2血清特異性IgE
(sIgE)和IgG4 (sIgG4)的變化，并評(píng)價(jià)其臨床療效。②我們回顧性分析了51名5 - 16歲被診斷為變應(yīng)性鼻炎和/或哮喘的戶塵螨過(guò)敏兒童，這些兒童經(jīng)過(guò)36個(gè)月的特異性免疫治療。我們還收集了同期對(duì)照隊(duì)列的50名服用常規(guī)藥物治療HDM過(guò)敏患者的數(shù)據(jù)。在研究組中，我們記錄了基線時(shí)以及特異性免疫治療6、12、24和36個(gè)月時(shí)的對(duì)HDM戶塵螨全部過(guò)敏原 (Der p)、Der p1和Der p2 的sIgE和sIgG4的水平。③血清sIgE反應(yīng)在SIT6個(gè)月后升高，但隨后下降。在36個(gè)月時(shí)，抗p1和抗p2 sIgEs下降到基線以下。在SIT時(shí)，對(duì)Der p血清sIgG4的反應(yīng)最大，其次是Der p1和Der p2。Der 1的sIgE/sIgG4比值的下降高于其他過(guò)敏原的最大降幅。與年齡較大的兒童相比，5 - 8歲兒童的sIgG4應(yīng)答更為明顯，尤其對(duì)Der p1和Der p2。④ HDM特異性免疫治療早期刺激了對(duì)HDM過(guò)敏原sIgE和sIgG4應(yīng)答。隨著sIgE/sIgG4比值的逐漸下降，特別是針對(duì)Der p1的sIgE/sIgG4。年幼的孩子可能比年長(zhǎng)的孩子表現(xiàn)出更快速的SIT反應(yīng)。
　　延伸閱讀
JACI：
Altered Serum IgE and IgG4 Response to Dermatophagoides Pteronyssinus Allergens during Specific Immunotherapy
DOI: https://doi.org/10.1016/j.jaci.2015.12.202 |
Abstract:
Background
Rationale
We investigated the changes in serum-specific IgE (sIgE) and IgG4 (sIgG4) against house dust mite (HDM) and its components Der p 1 and Der p 2 during specific immunotherapy (SIT), and evaluated the clinical efficacy thereof.
Methods
We retrospectively analyzed 51 HDM-sensitized children aged 5 to 16 years diagnosed with allergic rhinitis and/or asthma, following 36 months of SIT. We also collected data from a contemporary control cohort of 50 patients administered routine medications for HDM allergy. . In the test cases, we recorded the sIgE and sIgG4 levels against the whole allergen of HDM (Der p), Der p 1 and Der p 2 at baseline and at 6, 12, 24 and 36 months of SIT.
Results
The serum sIgE response increased up to 6 months of SIT, but subsequently declined. At 36 months, the anti-Der p 1 and anti-Der p 2 sIgEs plummeted below the baseline. During SIT, the increased serum sIgG4 response was the greatest against Der p, followed by Der p 1 and Der p 2. The decline in sIgE/sIgG4 ratio for Der 1 was higher than for the other allergensmaximum decline. Compared with older children, children aged 5 to 8 manifested a clearer sIgG4 response, especially against Der p 1 and Der p 2 versus Der p.
Conclusions
SIT for HDM stimulated an early sIgE and sIgG4 response against HDM allergens. with a progressive decline in the ratio of sIgE/sIgG4, especially against Der p 1. Younger children may manifest a more rapid response to SIT than older ones.
All Author:
Baoqing Sun, MHA, Zheng Peiya
　　創(chuàng)建過(guò)敏性疾病的科研、科普知識(shí)交流平臺(tái)，為過(guò)敏患者提供專業(yè)診斷、治療、預(yù)防的共享平臺(tái)。