原標(biāo)題：共同的基因變異提示過(guò)敏和自身免疫性疾病的共同途徑
　　①過(guò)敏和自身免疫性疾病之間的關(guān)系是復(fù)雜的，了解很少。②我們?cè)噲D研究過(guò)敏和自身免疫性疾病在基因位點(diǎn)和途徑上的共性，以闡明共同的疾病機(jī)制。③我們薈萃分析了兩項(xiàng)全基因組范圍內(nèi)關(guān)于自我報(bào)告的過(guò)敏和致敏的相關(guān)性研究，共包括62,330名受試者。這些結(jié)果被用來(lái)計(jì)算與自身免疫性疾病相關(guān)的單核苷酸多態(tài)性(SNPs)的富集。此外，我們還探索了遺傳途徑和轉(zhuǎn)錄因子結(jié)合位點(diǎn)的富集，并利用編碼路線圖DNA -超敏感位點(diǎn)數(shù)據(jù)計(jì)算了不同細(xì)胞中基因調(diào)控區(qū)域的敏感SNP富集，從而表征了組織特異性調(diào)控位點(diǎn)上不同負(fù)擔(dān)的共性。最后，我們將過(guò)敏數(shù)據(jù)與所有已知疾病的數(shù)據(jù)進(jìn)行了比較。④在先前與16種自身免疫性疾病相關(guān)的290個(gè)基因座中，我們發(fā)現(xiàn)與過(guò)敏相關(guān)的29個(gè)基因座(P = 1.4e-17)顯著富集，偽發(fā)現(xiàn)率小于0.05。這種富集似乎是自身免疫性疾病的一個(gè)普遍特征。在常見(jiàn)基因座中，48%對(duì)過(guò)敏和自身免疫性疾病有相同的作用方向。此外，我們還觀察到免疫細(xì)胞中染色質(zhì)通路和區(qū)域內(nèi)的敏感SNP富集，這在自身免疫性疾病患者中也有體現(xiàn)，但在其他疾病患者中沒(méi)有。⑤我們確定了過(guò)敏和自身免疫性疾病之間的易感性位點(diǎn)和通路的共性，提示了共同的疾病機(jī)制。對(duì)這些共同遺傳機(jī)制的進(jìn)一步研究可能有助于理解這些疾病之間的復(fù)雜關(guān)系，包括疾病流行率的平行增加。


　　延伸閱讀
JACI：
Shared genetic variants suggest common pathways in allergy and autoimmune diseases
September 2017Volume 140, Issue 3, Pages 771–781
DOI: https://doi.org/10.1016/j.jaci.2016.10.055
Abstract:
Background
The relationship between allergy and autoimmune disorders is complex and poorly understood.
Objective
We sought to investigate commonalities in genetic loci and pathways between allergy and autoimmune diseases to elucidate shared disease mechanisms.
Methods
We meta-analyzed 2 genome-wide association studies on self-reported allergy and sensitization comprising a total of 62,330 subjects. These results were used to calculate enrichment for single nucleotide polymorphisms (SNPs) previously associated with autoimmune diseases. Furthermore, we probed for enrichment within genetic pathways and of transcription factor binding sites and characterized commonalities in variant burden on tissue-specific regulatory sites by calculating the enrichment of allergy SNPs falling in gene regulatory regions in various cells using Encode Roadmap DNase-hypersensitive site data. Finally, we compared the allergy data with those of all known diseases.
Results
Among 290 loci previously associated with 16 autoimmune diseases, we found a significant enrichment of loci also associated with allergy (P = 1.4e-17) encompassing 29 loci at a false discovery rate of less than 0.05. Such enrichment seemed to be a general characteristic for autoimmune diseases. Among the common loci, 48% had the same direction of effect for allergy and autoimmune diseases. Additionally, we observed an enrichment of allergy SNPs falling within immune pathways and regions of chromatin accessible in immune cells that was also represented in patients with autoimmune diseases but not those with other diseases.
Conclusion
We identified shared susceptibility loci and commonalities in pathways between allergy and autoimmune diseases, suggesting shared disease mechanisms. Further studies of these shared genetic mechanisms might help in understanding the complex relationship between these diseases, including the parallel increase in disease prevalence.
All Author:
Eskil Kreiner, MD, PhD?, Johannes Waage, PhD?, Marie Standl, PhD, Susanne Brix, PhD, Tune H. Pers, PhD, Alexessander Couto Alves, PhD, Nicole M. Warrington, PhD, Carla M.T. Tiesler, MSc, Elaine Fuertes, PhD, Lude Franke, PhD, Joel N. Hirschhorn, MD, PhD, Alan James, MD, Angela Simpson, MD, PhD, Joyce Y. Tung, PhD, Gerard H. Koppelman, MD, PhD, Dirkje S. Postma, MD, PhD, Craig E. Pennell, MD, PhD, Marjo-Riitta Jarvelin, MD, Adnan Custovic, MD, PhD, Nicholas Timpson, PhD, Manuel A. Ferreira, PhD, David P. Strachan, MD, John Henderson, MD, David Hinds, PhD, Hans Bisgaard, MD, DMSc'Correspondence information about the author MD, DMSc Hans Bisgaard Email the author MD, DMSc Hans Bisgaard, Klaus B?nnelykke, MD, PhD
　　創(chuàng)建過(guò)敏性疾病的科研、科普知識(shí)交流平臺(tái)，為過(guò)敏患者提供專業(yè)診斷、治療、預(yù)防的共享平臺(tái)。