原標(biāo)題：榛子過敏原組份檢測在確定榛子敏感性中的作用
　?、僖郧暗难芯勘砻?，與皮膚點(diǎn)刺試驗(yàn)(SPT)和榛子特異性IgE檢測 (hIgE)相比，榛子組分檢測(HCT)可能是樺樹花粉過敏患者臨床反應(yīng)性更好的指標(biāo)。榛子過敏原組份檢測在確定臨床反應(yīng)性中的有效性表明在目前的臨床管理中存在潛在的不足。②回顧性分析了6例進(jìn)行了包含Cor a1、8、9、14的榛子過敏原組份檢測的病例。由于之前的過敏試驗(yàn)和榛子特異性IgE檢測呈陽性(1例患者SPT陽性)，榛子過敏原組份檢測時(shí)沒有患者食用含有榛子的產(chǎn)品(PCH)。四名患者在過敏測試前報(bào)告了對榛子產(chǎn)品的耐受性，一名患者沒有接觸過榛子產(chǎn)品，一名患者在攝入榛子產(chǎn)品后喉嚨發(fā)癢。對統(tǒng)計(jì)數(shù)據(jù)、樺樹花粉特異性IgE (bIgE)、榛子特異性IgE水平、SPT結(jié)果、榛子Cor a 1、8、9、14特異性IgE水平和榛子產(chǎn)品激發(fā)試驗(yàn)結(jié)果以圖表方式進(jìn)行回顧性分析。③總IgE平均值為411.11（SD: 529.07; N: 6），榛子特異性IgE平均值為15.95（SD=17.36; N=6），樺樹花粉特異性IgE平均值為9.57（SD=45.06; N=6），Cor a 1=29.85 (SD=40.16; N=6), Cor a 8=0.1 (SD=1.52; N=6), Cor a 9=0.34 (SD=0.53; N=6), and Cor a 14=0.27 (SD=0.27; N=6).6例中的5例在他們的飲食中引入榛子產(chǎn)品，他們的Cor a 1=35.80 (SD=41.84; N=5)，Cor a 9=0.12 (SD=0.06; N=5)，而飲食中沒有引入榛子產(chǎn)品的那例病人Cor a 1=0.1 和 Cor a 9=1.43④這是對榛子組份檢測作用的初步研究，本研究顯示，榛子組份檢測能確定榛子特異性IgE陽性的樺樹花粉過敏病人的臨床反應(yīng)性。
延伸閱讀
JACI:
The Efficacy of Hazelnut IgE Component Testing in Determining Hazelnut Sensitivity
DOI: https://doi.org/10.1016/j.jaci.2017.12.773
Abstract:
Rationale
Prior studies indicate that hazelnut component testing (HCT) may serve as a better indicator for clinical reactivity than skin prick (SPT) and hazelnut-specific IgE testing (hIgE) in patients with birch pollen allergy. The efficacy of HCT in determining clinical reactivity represents a potential gap in clinical management.
Methods
A retrospective chart review was performed on six patients who underwent HCT to Cor a 1, 8, 9, and 14. None of the patients ate products containing hazelnut (PCH) at the time of HCT due to prior positive allergy testing with hIgE testing (one patient had positive SPT). Four of the patients reported tolerating PCH prior to allergy testing, one had no exposures, and one developed throat itching upon ingestion. The charts were reviewed for demographic data, birch specific IgE (bIgE), hIgE levels, SPT test results, hazelnut Cor a 1, 8, 9, and 14 levels, and trial of PCH.
Results
Average total IgE=411.11 (SD: 529.07; N: 6), hIgE=15.95 (SD=17.36; N=6), bIGE=9.57 (SD=45.06; N=6), Cor a 1=29.85 (SD=40.16; N=6), Cor a 8=0.1 (SD=1.52; N=6), Cor a 9=0.34 (SD=0.53; N=6), and Cor a 14=0.27 (SD=0.27; N=6). Five of six patients introduced PCH into their diet. Their average Cor a 1=35.80 (SD=41.84; N=5) and Cor a 9=0.12 (SD=0.06; N=5) versus the one patient who did not introduce PCH (Cor a 1=0.1 and Cor a 9=1.43).
Conclusions
This was a pilot study undertaken to investigate the utility of HCT. This study suggests that HCT can determine clinical reactivity in birch pollen allergic patients with positive hIgE.
All Author:
Joel P. Brooks, DO, Francis M. Lobo, MD
　　創(chuàng)建過敏性疾病的科研、科普知識交流平臺，為過敏患者提供專業(yè)診斷、治療、預(yù)防的共享平臺。