原標(biāo)題：中國(guó)病人花生過(guò)敏原組份分析
　?、倌康模夯ㄉ且环N重要的食物過(guò)敏原，其臨床嚴(yán)重程度和患病率不斷上升，尤其是在一些西方國(guó)家。然而，來(lái)自中國(guó)的研究數(shù)據(jù)很少。②方法：詳細(xì)病史;花生皮膚點(diǎn)刺破試驗(yàn);花生特異性IgE (ImmunoCAP);花生提取液SDS-PAGE電泳，免疫印跡。③結(jié)果：8名受試者的平均年齡為24歲，從3歲到64歲不等?；ㄉ崛∵^(guò)程中鑒定出14條蛋白條帶，其中63 kd、41.7 kd、39 kd、34.8 kd、17.9 kd蛋白豐富條帶5條。過(guò)敏病人血清至少識(shí)別出8個(gè)條帶。這些過(guò)敏的蛋白質(zhì)分子量為17.9 kd(4/8),23.5 kd(被血清4/8),41.7 kd(被血清4/8),48.5 kd(被血清5/8),63 kd(4/8),34.8 kd(1/8),39 kd(3/8),53 kd(2/8)。結(jié)論：④患者對(duì)花生致敏成分的反應(yīng)存在個(gè)體差異。
延伸閱讀
JACI:
Analysis of Peanut Allergenic Components for Chinese Patients
DOI: https://doi.org/10.1016/j.jaci.2006.11.466
Abstract:
Abstract
RATIONALE: Peanut is an important food allergen because of its clinical severity and increasing prevalence, especially in some western countries. However few data came from China.
METHODS: A careful history; skin prick test for peanut; specific IgE for peanut (ImmunoCAP); peanut challenge test, SDS-PAGE electrophoresis for peanut extract, immunoblot.
RESULTS: Eight subjects had the mean age 24 ranging from 3 to 64 years old. Fourteen protein bands were identified in the peanut extraction, with five protein abundant bands at 63 kd, 41.7 kd, 39 kd, 34.8 kd, and 17.9 kd. At least eight bands were identified by the allergic sera. These allergenic proteins had molecular weights of 17.9 kd (recognized by 4/8 sera), 23.5 kd (recognized by 4/8 sera), 41.7 kd (recognized by 4/8 sera), 48.5 kd (recognized by 5/8 sera), 63 kd (recognized by 4/8 sera), 34.8 kd (recognized by 1/8 sera), 39 kd (recognized by 3/8 sera), 53 kd (recognized by 2/8 sera).respectively.
CONCLUSIONS: Patients showed individual difference in view of reaction to the peanut allergenic components
Author:
H. Li
　　創(chuàng)建過(guò)敏性疾病的科研、科普知識(shí)交流平臺(tái)，為過(guò)敏患者提供專(zhuān)業(yè)診斷、治療、預(yù)防的共享平臺(tái)。